Kotschy, András


Kotschy, András
Servier Research Institute of Medicinal Chemistry, Budapest, Hungary

Biography:
András Kotschy is the managing director of the Servier Research Institute of Medicinal Chemistry in Budapest, Hungary. After completing his PhD degree in 1995 he joined the staff of Eötvös Loránd University where he rose through the ranks to associate professor also completing his habilitation and obtaining a DSc degree. His research interests included the development of new synthetic methodologies, transition metal catalysis in particular, and their application to heterocyclic chemistry.
In 2007 he joined the newly established Servier Research Institute of Medicinal Chemistry as director of the Discovery Chemistry division and in 2015 he became managing director of the institute. Since 2007 he has been in charge of multiple research projects in oncology and metabolism. András Kotschy is the author of 56 refereed publications that received over 1000 citations, 1 book, 2 book chapters, and 10 patents. He is also the recipient of multiple scientific awards and fellowships.

Lecture:
Restoring programmed cell death – a new approach in cancer therapy

Tumour cells that harbour genetic mutations and are recognised as abnormal should be naturally eliminated but they maintain their existence by a combination of multiple activities – also known as the hallmarks of cancer. One of these hallmarks is the evasion of apoptosis, the programmed cell death. The restoration of the apoptotic cascade in tumour cells has long been recognised as a promising way to treat cancer but the major members of this protein family, BCL2, MCL1, and BCL-xL have long remained elusive targets decades long for drug discovery. Recently the decade long efforts of the pharmaceutical industry have been rewarded by the identification of potent and selective inhibitors for some family members.

The presentation overviews the principal pharmacological and chemical challenges of targeting this protein family and presents the recent scientific [1] and pharmacological achievements in this area.

[1] Kotschy A., Szlávik Z., Murray J. et al. Nature, 538, 477-482 (2016).