Kilicarslan Muge

Kilicarslan Muge
Ankara University, Faculty of Pharmacy, Department of Pharmacutical Technology, 06100 Tandoğan, Ankara, Turkey

Muge Kilicarslan is Associate Professor of Pharmaceutical Technology at Ankara University, Faculty of Pharmacy, Turkey. She is graduated from Ankara University Faculty of Pharmacy in 1990. She received her M.Sc. degree on Pharmaceutical Technology with her thesis on the formulation of some drugs conserve in plastic syringes in the same university. She obtained her Ph.D. degree in 1999 on the preparation of multiparticulate oral controlled release dosage form of verapamil HCl. She studied on the in situ implants at College of Pharmacy, Institute of Pharmaceutical Technology, Freie Universitat, Berlin for post-doctoral research. Dr. Kilicarslan worked as Assistant Professor from 2010 to 2015 and received her Associate Professor title in 2015 at the same faculty and department. She studied at several research projects as assistant researcher and research manager. She is currently continuing her research work at the same department. Her current research interest revolves around micro and nanoparticulate drug delivery systems, micromeritics, dental and periodontal drug delivery systems and in situ implants. Her interests also include Good Manufacturing Practices, Quality Assurance and Quality by Design. She is writer of a national book chapter and one of the writers of national book. She has more than twenty papers in the international and national journals and has given several poster presentations and invited lectures. She is also serving as Vice Dean of Faculty of Pharmacy at Ankara University since June 2016.

New Drug Delivery Systems for the Oral Cavity and Periodontal Therapy

In this lecture especially the drug delivery from periodontal pocket and new systems will be described after discussing the systemic and local drug delivery through oral mucosa and key considerations in the design and development of a drug delivery systems intended for use of oral cavity. Periodontal diseases are several pathological conditions in oral cavity and in recent years local drug delivery into the periodontal pocket has been investigated to overcome the disadvantages of systemic antimicrobial therapy.The periodontal pocket provides a natural reservoir, which is easily accessible for the insertion of local drug delivery devices. In my researches clindamycine phosphate (CDP) and metronidazole benzoate (MNZ) have been chosen as model drugs. CDP loaded microparticles were prepared by spray drying method-using chitosan at one of my research and delayed drug release more than one week and minimum of 7 days’ sustained antimicrobial activity could be obtained. It can be concluded that the easy scale up of spray drying method, the appropriate particle size, bioadhesive properties of chitosan were appropriate characteristics of these formulations for application into periodontal pocket (1). In situ implants containing MNZ for periodontal therapy were prepared at the other research by using PLGA 502H and 502S with different solvents. Using some adhesive polymers was novelty for in situ implants to maintain the longer retention time (2). MNZ loaded ethyl cellulose microspheres and NaCMC, Methocel K15M and K100M films were also studied. Than microsphere embedded adhesive films were prepared due to the difficulty of insertion of microspheres alone and burst release of drug could be decreased by that combination. Furthermore, CDP loaded chitosan films, CDP loaded chitosan-alginate complex films were studied. Our studies on periodontal nanoparticles are in progress.

1) Kilicarslan M et al., Curr. Drug. Deliv., 11, 98-111, (2014).
2) Kilicarslan M, et al., Drug Dev. Ind. Pharm.,40 (5), 619-624, (2014).

Kilicarslan, Muge
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, 06100 Tandogan, Ankara, Turkey